Highlighting (green) significant amino acid variants in highly conserved domains of proteins of interest using AlphaFold and ChimeraX after alignment of thousands of proteins
What metabolites are differentially expressed among experimental and control groups?
Welcome!
I am a Bioinformatics PhD candidate at the University of Georgia. I bring deep expertise in omics analytical pipelines, with a particular strength in metagenomics and multi-omic integration. I'm interested in using computational biology to identify variants in highly conserved protein domains of gut bacteria that may influence disease through the gut-brain axis as well as projects involving the development of AI for rigorous statistical analyses in science and technology. Prior to beginning my graduate program, I worked as a researcher at the Centers for Disease Control & Prevention in the Office of Blood, Organ, & Other Tissue Safety and studied Cryptococcus transmission events in solid organ transplantations, which led to my interest in bioinformatics and computational biology. My thesis work in graduate school involves in-depth analyses of variants in the gut microbiome and potential implications for neurological diseases as well as a broad-scale metagenomics assessment of the potential of bioaerosolization of pathogenic bacteria from the water to the surrounding air in low-to-middle income countries.
Publications:
Penumarthi, L.R., Baptista, R.P., Beaudry, M.S., Glenn, T.C., Kissinger, J.C., A new chromosome-level genome assembly and annotation of Cryptosporidium meleagridis. Scientific Data, 2024.
Penumarthi, L.R., La Hoz, R.M., Wolfe, C.R., Jackson, B.R., Mehta, A.K, Malinis, M., Danziger-Isakov, L., Strasfeld, L., Florescu, D.F., Vce, G., Basavaraju, S.V., Michaels, M.G., Cryptococcus transmission through solid organ transplantation in the United States: A report from the Ad Hoc Disease Transmission Advisory Committee. Am J Transplant, 2021. 21(5): p. 1911-1923